Accès gratuit
Méd. Intensive Réa.
Volume 27, Numéro 6, Novembre 2018
Néphrologie et métabolisme
Page(s) 510 - 521
Section Mise au point / Update
Publié en ligne 7 décembre 2018
  • European Association for the Study of the Liver, (2018) EASL Clinical Practice Guidelines: management of alcohol-related liver disease. J Hepatol 69: 154–181 [CrossRef] [PubMed] [Google Scholar]
  • Mathurin P, Mendenhall CL, Carithers RL, Ramond MJ, Maddrey WC, Garstide P, Rueff B, Naveau S, Chaput JC, Poynard T, (2002) Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol 36: 480–487 [CrossRef] [PubMed] [Google Scholar]
  • Mathurin P, O’Grady J, Carithers RL, Phillips M, Louvet A, Mendenhall CL, Ramond MJ, Naveau S, Maddrey WC, Morgan TR, (2011) Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 60: 255–260 [CrossRef] [PubMed] [Google Scholar]
  • Ciocan D, Rebours V, Voican CS, Wrzosek L, Puchois V, Cassard AM, Perlemuter G, (2018) Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. Sci Rep 8: 4822 [CrossRef] [PubMed] [Google Scholar]
  • Llopis M, Cassard AM, Wrzosek L, Boschat L, Bruneau A, Ferrere G, Puchois V, Martin JC, Lepage P, Le Roy T, Lefèvre L, Langelier B, Cailleux F, González-Castro AM, Rabot S, Gaudin F, Agostini H, Prévot S, Berrebi D, Ciocan D, Jousse C, Naveau S, Gérard P, Perlemuter G, (2016) Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease. Gut 65: 830–839 [CrossRef] [PubMed] [Google Scholar]
  • Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW, (1996) Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 23: 155–163 [CrossRef] [PubMed] [Google Scholar]
  • Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC, (1992) Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16: 1423–1427 [CrossRef] [PubMed] [Google Scholar]
  • Oh SI, Kim CI, Chun HJ, Park SC, (1998) Chronic ethanol consumption affects glutathione status in rat liver. J Nutr 128: 758–763 [PubMed] [Google Scholar]
  • Lands WE, (1995) Cellular signals in alcohol-induced liver injury: a review. Alcohol Clin Exp Res 19: 928–938 [PubMed] [Google Scholar]
  • Colell A, García-Ruiz C, Miranda M, Ardite E, Marí M, Morales A, Corrales F, Kaplowitz N, Fernández-Checa JC, (1998) Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115: 1541–1551 [CrossRef] [PubMed] [Google Scholar]
  • Adachi Y, Bradford BU, Gao W, Bojes HK, Thurman RG, (1994) Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20: 453–460 [CrossRef] [PubMed] [Google Scholar]
  • Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H, (2000) Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32: 1008–1017 [CrossRef] [PubMed] [Google Scholar]
  • Pritchard MT, McMullen MR, Stavitsky AB, Cohen JI, Lin F, Edward Medof M, Nagy LE, (2007) Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132: 1117–1126 [CrossRef] [PubMed] [Google Scholar]
  • Miller AM, Horiguchi N, Jeong WI, Radaeva S, Gao B, (2011) Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res 35: 787–793 [PubMed] [Google Scholar]
  • Hrubec Z, Omenn GS, (1981) Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 5: 207–215 [PubMed] [Google Scholar]
  • Nguyen-Khac E, Houchi H, Daoust M, Dupas JL, Naassila M, (2008) The -308 TNFalpha gene polymorphism in severe acute alcoholic hepatitis: identification of a new susceptibility marker. Alcohol Clin Exp Res 32: 822–828 [PubMed] [Google Scholar]
  • Louvet A, Wartel F, Castel H, Dharancy S, Hollebecque A, Canva-Delcambre V, Deltenre P, Mathurin P, (2009) Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor. Gastroenterology 137: 541–548 [CrossRef] [PubMed] [Google Scholar]
  • Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI, (1978) Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 75: 193–199 [CrossRef] [PubMed] [Google Scholar]
  • Carithers RL, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, Maddrey WC, (1989) Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. Ann Intern Med 110: 685–690 [CrossRef] [PubMed] [Google Scholar]
  • Sheth M, Riggs M, Patel T, (2002) Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis. BMC Gastroenterol 2: 2 [CrossRef] [PubMed] [Google Scholar]
  • Soultati AS, Dourakis SP, Alexopoulou A, Deutsch M, Vasilieva L, Archimandritis AJ, (2006) Predicting utility of a model for end stage liver disease in alcoholic liver disease. World J Gastroenterol 12: 4020–4025 [CrossRef] [PubMed] [Google Scholar]
  • Forrest EH, Morris AJ, Stewart S, Phillips M, Oo YH, Fisher NC, Haydon G, O’Grady J, Day CP, (2007) The Glasgow alcoholic hepatitis score identifies patients who may benefit from corticosteroids. Gut 56:1743–1746 [CrossRef] [PubMed] [Google Scholar]
  • Dominguez M, Rincón D, Abraldes JG, Miquel R, Colmenero J, Bellot P, García-Pagán JC, Fernández R, Moreno M, Bañares R, Arroyo V, Caballería J, Ginès P, Bataller R, (2008) A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am J Gastroenterol 103: 2747–2756 [Google Scholar]
  • EH Forrest, NC Fisher, S Singhal, A Brind, G Haydon, J O’Grady, PC Hayes, CP Day, (2010) Comparison of the Glasgow alcoholic hepatitis score and the ABIC score for the assessment of alcoholic hepatitis. Am J Gastroenterol 105: 701–702 (doi: 10.1038/ajg.2009.645) [Google Scholar]
  • O’Shea RS, Dasarathy S, McCullough AJ, Practice Parameters Committee of the American College of Gastroenterology, (2010) Alcoholic liver disease. Hepatology 51: 307–328 [CrossRef] [PubMed] [Google Scholar]
  • Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL–CLIF Consortium, (2013) Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 144: 1426–1437, 1437.e1-9 [CrossRef] [PubMed] [Google Scholar]
  • Sersté T, Cornillie A, Njimi H, Pavesi M, Arroyo V, Putignano A, Weichselbaum L, Deltenre P, Degré D, Trépo E, Moreno C, Gustot T, (2018) The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis. J Hepatol 69: 318–324 [CrossRef] [PubMed] [Google Scholar]
  • Kryger P, Schlichting P, Dietrichson O, Juhl E, (1983) The accuracy of the clinical diagnosis in acute hepatitis and alcoholic liver disease. Clinical versus morphological diagnosis. Scand J Gastroenterol 18: 691–6 [CrossRef] [PubMed] [Google Scholar]
  • Thabut D, Naveau S, Charlotte F, Massard J, Ratziu V, Imbert-Bismut F, Cazals-Hatem D, Abella A, Messous D, Beuzen F, Munteanu M, Taieb J, Moreau R, Lebrec D, Poynard T, (2006) The diagnostic value of biomarkers (AshTest®) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. J Hepatol 44: 1175–1185 [CrossRef] [PubMed] [Google Scholar]
  • Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, Abenavoli L, D’Angelo C, Caputo F, Zambon A, Haber PS, Gasbarrini G, (2007) Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 370: 1915–1922 [CrossRef] [PubMed] [Google Scholar]
  • Plauth M, Cabré E, Riggio O, Assis-Camilo M, Pirlich M, Kondrup J, Ferenci P, Holm E, Vom Dahl S, Müller MJ, Nolte W; ESPEN (European Society for Parenteral and Enteral Nutrition), (2006) ESPEN guidelines on enteral nutrition: liver disease. Clin Nutr 25: 285–294 [CrossRef] [PubMed] [Google Scholar]
  • Cabré E, Rodríguez-Iglesias P, Caballería J, Quer JC, Sánchez-Lombraña JL, Parés A, Papo M, Planas R, Gassull MA, (2000) Short-and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial. Hepatology 32: 36–42 [CrossRef] [PubMed] [Google Scholar]
  • Moreno C, Deltenre P, Senterre C, Louvet A, Gustot T, Bastens B, Hittelet A, Piquet MA, Laleman W, Orlent H, Lasser L, Sersté T, Starkel P, De Koninck X, Negrin Dastis S, Delwaide J, Colle I, de Galocsy C, Francque S, Langlet P, Putzeys V, Reynaert H, Degré D, Trépo E, (2016) Intensive Enteral Nutrition Is Ineffective for Patients With Severe Alcoholic Hepatitis Treated With Corticosteroids. Gastroenterology 150: 903–910.e8 [CrossRef] [PubMed] [Google Scholar]
  • Rambaldi A, Saconato HH, Christensen E, Thorlund K, Wetterslev J, Gluud C, (2008) Systematic review: glucocorticosteroids for alcoholic hepatitis — a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials. Aliment Pharmacol Ther 27: 1167–1178 [Google Scholar]
  • Singh S, Murad MH, Chandar AK, Bongiorno CM, Singal AK, Atkinson SR, Thursz MR, Loomba R, Shah VH, (2015) Comparative effectiveness of pharmacological interventions for severe alcoholic hepatitis: a systematic review and network metaanalysis. Gastroenterology 149: 958–970.e12 [CrossRef] [PubMed] [Google Scholar]
  • Louvet A, Thursz MR, Kim DJ, Labreuche J, Atkinson SR, Sidhu SS, O’Grady JG, Akriviadis E, Sinakos E, Carithers RL, Ramond MJ, Maddrey WC, Morgan TR, Duhamel A, Mathurin P, (2018) Corticosteroids reduce risk of death within 28 days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo-a meta-analysis of individual data from controlled trials. Gastroenterology 155: 458–468.e8 [CrossRef] [PubMed] [Google Scholar]
  • Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O’Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial, (2015) Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med 372: 1619–1628 [CrossRef] [PubMed] [Google Scholar]
  • Phillips M, Curtis H, Portmann B, Donaldson N, Bomford A, O’Grady J, (2006) Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis — a randomised clinical trial. J Hepatol 44: 784–790 [CrossRef] [PubMed] [Google Scholar]
  • Moreno C, Langlet P, Hittelet A, Lasser L, Degré D, Evrard S, Colle I, Lemmers A, Devière J, Le Moine O, (2010) Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial. J Hepatol 53: 1117–1122 [CrossRef] [PubMed] [Google Scholar]
  • Stewart S, Prince M, Bassendine M, Hudson M, James O, Jones D, Record C, Day CP, (2007) A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol 47: 277–283 [CrossRef] [PubMed] [Google Scholar]
  • Nguyen-Khac E, ThevenoT t, Piquet MA, Benferhat S, Hezam A, Goria O, Tramier B, Chatelain D, Dupas JL, (2008) Antioxidants plus corticosteroids in the treatment of severe acute alcoholic hepatitis: the question is still open. J Hepatol 49: 147–148 (author reply 148. doi: 10.1016/j.jhep.2008.04.003. Epub 2008 Apr 28) [CrossRef] [PubMed] [Google Scholar]
  • Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B, Dupas JL; AAHNAC Study Group, (2011) Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med 365: 1781–1789 [CrossRef] [PubMed] [Google Scholar]
  • Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O, (2000) Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 119: 1637–1648 [CrossRef] [PubMed] [Google Scholar]
  • Whitfield K, Rambaldi A, Wetterslev J, Gluud C, (2009) Pentoxifylline for alcoholic hepatitis. Cochrane Database Syst Rev 4: CD007339 (doi: 10.1002/14651858.CD007339.pub2) [Google Scholar]
  • Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet MA, Davion T, Oberti F, Broët P, Emilie D; Foie-Alcool group of the Association française pour l’étude du foie, (2004) A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology 39: 1390–1397 [CrossRef] [PubMed] [Google Scholar]
  • Boetticher NC, Peine CJ, Kwo P, Abrams GA, Patel T, Aqel B, Boardman L, Gores GJ, Harmsen WS, McClain CJ, Kamath PS, Shah VH, (2008) A randomized, double-blinded, placebocontrolled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology 135: 1953–1960 [CrossRef] [PubMed] [Google Scholar]
  • Dubuquoy L, Louvet A, Lassailly G, Truant S, Boleslawski E, Artru F, Maggiotto F, Gantier E, Buob D, Leteurtre E, Cannesson A, Dharancy S, Moreno C, Pruvot FR, Bataller R, Mathurin P, (2015) Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis. Gut 64: 1949–1960 [CrossRef] [PubMed] [Google Scholar]
  • Spahr L, Lambert JF, Rubbia-Brandt L, Chalandon Y, Frossard JL, Giostra E, Hadengue A, (2008) Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial. Hepatology 48: 221–229 [CrossRef] [PubMed] [Google Scholar]
  • Singh V, Sharma AK, Narasimhan RL, Bhalla A, Sharma N, Sharma R, (2014) Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study. Am J Gastroenterol 109: 1417–1423 [Google Scholar]
  • Singh V, Keisham A, Bhalla A, Sharma N, Agarwal R, Sharma R, Singh A, (2018) Efficacy of granulocyte colony-stimulating factor and N-acetylcysteine therapies in patients with severe alcoholic hepatitis. Clin Gastroenterol Hepatol 16: 1650–1656.e2 (doi: 10.1016/j.cgh.2018.01.040. Epub 2018 Jan 31) [CrossRef] [PubMed] [Google Scholar]
  • Spahr L, Chalandon Y, Terraz S, Kindler V, Rubbia-Brandt L, Frossard JL, Breguet R, Lanthier N, Farina A, Passweg J, Becker CD, Hadengue A, (2013) Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: a randomized controlled trial. PLoS One 8: e53719 [CrossRef] [PubMed] [Google Scholar]
  • Sen S, Mookerjee RP, Cheshire LM, Davies NA, Williams R, Jalan R, (2005) Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis. J Hepatol 43: 142–148 [CrossRef] [PubMed] [Google Scholar]
  • Jalan R, Sen S, Steiner C, Kapoor D, Alisa A, Williams R, (2003) Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. J Hepatol 38: 24–31 [CrossRef] [PubMed] [Google Scholar]
  • Boitard J, Louvet A, Bismuth B, Dharancy S, Wartel F, Canva-Delcambre V, Deltenre P, Jude B, Fourrier F, Mathurin P, (2008) Tolerance and efficacy of the mars system in patients with severe alcoholic hepatitis non-responders to steroids: a pilot study. J Hepatol 48: s355–s356 [Google Scholar]
  • Bañares R, Nevens F, Larsen FS, Jalan R, Albillos A, Dollinger M, Saliba F, Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brünnler T, Kramer L, Mathurin P, de la Mata M, Gasbarrini A, Müllhaupt B, Wilmer A, Laleman W, Eefsen M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R, Arroyo V; RELIEF study group, (2013) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial. Hepatology 57: 1153–1162 [CrossRef] [PubMed] [Google Scholar]
  • Thompson J, Jones N, Al-Khafaji A, Malik S, Reich D, Munoz S, MacNicholas R, Hassanein T, Teperman L, Stein L, Duarte-Rojo A, Malik R, Adhami T, Asrani S, Shah N, Gaglio P, Duddempudi A, Borg B, Jalan R, Brown R, Patton H, Satoskar R, Rossi S, Parikh A, ElSharkawy A, Mantry P, Sher L, Wolf D, Hart M, Landis C, Wigg A, Habib S, McCaughan G, Colquhoun S, Henry A, Bedard P, Landeen L, Millis M, Ashley R, Frank W, Henry A, Stange J, Subramanian R, VTI-208 Study Group, (2018) Extracorporeal Cellular Therapy (ELAD) in severe alcoholic hepatitis: a multinational, prospective, controlled, randomized trial. Liver Transpl 24: 380–393 [CrossRef] [PubMed] [Google Scholar]
  • Mathurin P, Abdelnour M, Ramond MJ, Carbonell N, Fartoux L, Serfaty L, Valla D, Poupon R, Chaput JC, Naveau S, (2003) Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology 38: 1363–1369 [CrossRef] [PubMed] [Google Scholar]
  • Louvet A, Labreuche J, Artru F, Boursier J, Kim DJ, O’Grady J, Trépo E, Nahon P, Ganne-Carrié N, Naveau S, Diaz E, Gustot T, Lassailly G, Cannesson-Leroy A, Canva-Delcambre V, Dharancy S, Park SH, Moreno C, Morgan TR, Duhamel A, Mathurin P, (2015) Combining Data From Liver Disease Scoring Systems Better Predicts Outcomes of Patients With Alcoholic Hepatitis. Gastroenterology 149: 398–406.e8 (quiz e16-7) [CrossRef] [PubMed] [Google Scholar]
  • Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, Dharancy S, Texier F, Hollebecque A, Serfaty L, Boleslawski E, Deltenre P, Canva V, Pruvot FR, Mathurin P, (2007) The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 45: 1348–1354 [CrossRef] [PubMed] [Google Scholar]
  • Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A, Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T, Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallée JC, (2011) Early liver transplantation for severe alcoholic hepatitis. N Engl J Med 365: 1790–1800 [CrossRef] [PubMed] [Google Scholar]
  • TM Antonini, O Guillaud, J Dumortier, S Dharancy, F Saliba, P Mathurin, JC Duclos-Vallée, C Duvoux; for Groupe de recherche français en greffe de foie (GReF2), (2018) Impact of a first study of early transplantation in acute alcoholic hepatitis: results of a nationwide survey in french liver transplantation programs. Liver Transpl 24: 841–844 (doi: 10.1002/lt.25039. Epub 2018 May 13) [CrossRef] [PubMed] [Google Scholar]
  • Im GY, Kim-Schluger L, Shenoy A, Schubert E, Goel A, Friedman SL, Florman S, Schiano TD, (2016) Early liver transplantation for severe alcoholic hepatitis in the United States — a Single-Center Experience. Am J Transplant 16: 841–849 [Google Scholar]
  • Lee BP, Chen PH, Haugen C, Hernaez R, Gurakar A, Philosophe B, Dagher N, Moore SA, Li Z, Cameron AM, (2017) Three-year results of a pilot program in early liver transplantation for severe alcoholic hepatitis. Ann Surg 265: 20–29 [CrossRef] [PubMed] [Google Scholar]
  • Lee BP, Mehta N, Platt L, Gurakar A, Rice JP, Lucey MR, Im GY, Therapondos G, Han H, Victor DW, Fix OK, Dinges L, Dronamraju D, Hsu C, Voigt MD, Rinella ME, Maddur H, Eswaran S, Hause J, Foley D, Ghobrial RM, Dodge JL, Li Z, Terrault NA, (2018) Outcomes of early liver transplantation for patients with severe alcoholic hepatitis. Gastroenterology 155: 422–430.e1 [CrossRef] [PubMed] [Google Scholar]
  • Marot A, Dubois M, Trépo E, Moreno C, Deltenre P, (2018) Liver transplantation for alcoholic hepatitis: a systematic review with meta-analysis. PLoS One 13: e0190823 [CrossRef] [PubMed] [Google Scholar]
  • Hmoud BS, Patel K, Bataller R, Singal AK, (2016) Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials. Liver Int 36: 721–728 [CrossRef] [PubMed] [Google Scholar]
  • Gustot T, Maillart E, Bocci M, Surin R, Trépo E, Degré D, Lucidi V, Taccone FS, Delforge ML, Vincent JL, Donckier V, Jacobs F, Moreno C, (2014) Invasive aspergillosis in patients with severe alcoholic hepatitis. J Hepatol 60: 267–274 [CrossRef] [PubMed] [Google Scholar]

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.